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If you travel the Lower Mississippi River, New Orleans will most likely be your start or final destination, and there is plenty to see and do here. There are ghost and voodoo tours that guide you through local history, the National WWII Museum, the Garden District, the French Quarter, Jackson Square, and lots of amazing restaurants to eat at. Elvis Presley is arguably the greatest thing ever to have come out of Memphis. But The National Civil Rights Museum should also be a stop during your visit to this Mississippi River cruise port. American Cruise Lines has an 11-day river cruise from New Orleans to St. Louis. This close-jaw Highlights of the Mississippi River cruise itinerary starts and ends in New Orleans.
American Queen Voyages shuts down: What to know about cruises, refunds - Commercial Appeal
American Queen Voyages shuts down: What to know about cruises, refunds.
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Night The Big Easy To The Gateway CityDetails
If we had to pick just one, September is the best month for a Mississippi River cruise. The weather is usually mild with less likelihood of rain, and autumn colors are beginning to paint the shoreline. Keep in mind, however, that the Mississippi is the fourth largest river in the world—so temperatures any time of year are not going to be the same in warmer Louisiana as they are in cooler Minnesota. The new kid on the Mississippi is the Viking Mississippi, a 386-passenger, five-deck vessel that first set sail in September 2022. The cutting-edge cruise is Viking’s first foray in the US, adding to their fleet of more than 90 ocean, river, and expedition vessels navigating the world’s seven continents. The challenge modern travelers now face is when, where, and how to go about this iconic American voyage.
Historic Mississippi River Cruise Itinerary

Explore Hannibal, “America’s Hometown,” a mere block from the ship, where Mark Twain’s home and museum illuminate the events that shaped his life and career. Elements of his childhood adventures were woven into classics like The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn. As you begin your amazing journey, relax on your private stateroom balcony and admire the beautiful views that stretch out before you. Get to know fellow guests in one of the lounges or at the evening cocktail hour. You can cruise all the way from New Orleans to Minneapolis, or you can sail shorter segments of the river.
Other Regions in USA
You can take a one-day excursion (that does not sail overnight and doesn’t go very far) or sign up for a cruise that is a minimum of 5 days. This includes American Cruise Lines American Symphony or American Melody, and Viking Mississippi. Guests can also look forward to discovering spacious lounges and quiet nooks to gather with fellow travelers. As you cruise the legendary Mississippi River, our dedicated crew will treat you with gracious hospitality and the utmost care. Enjoy the intimacy and comfort of small-ship cruising, where our crew will quickly learn your name and preferences as you travel with us. Our onboard experts don’t just lecture, they spend time with guests aboard and on shore, giving real insight and depth to each destination visited.
Davenport is your largest cruise port between St. Louis and St. Paul as one of the four “Quad Cities” that combine into a larger metro area. The first railroad to reach the Mississippi River connected Chicago to Rock Island, Illinois across the river. The area features diverse attractions ranging from grand historic mansions lining the river, renowned museums, rich Native American history, and the largest agricultural exhibit in the world. Be enlightened by the region’s history, culture, and environment at the Smithsonian-affiliated Putnam Museum. Cruise from New Orleans all the way up to St. Paul on Viking's 15- or 17-day America's Great River itinerary aboard the 193-stateroom Viking Mississippi, a vessel designed just for this river. The journey starts in New Orleans and stops in Baton Rouge; Natchez and Vicksburg, Mississippi; Memphis; and St. Louis, where passengers can explore attractions like Gateway Arch National Park and the flagship Anheuser-Busch brewery.
As the most discerning, up-to-the-minute voice in all things travel, Condé Nast Traveler is the global citizen’s bible and muse, offering both inspiration and vital intel. We understand that time is the greatest luxury, which is why Condé Nast Traveler mines its network of experts and influencers so that you never waste a meal, a drink, or a hotel stay wherever you are in the world. During this sailing, you'll overnight in Memphis, so there's time to fully savor barbecue, the blues and Elvis Presley's Graceland. A port call in Paducah, Kentucky, lets you explore the National Quilt Museum and colorful street murals.
A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the Mississippi River and continues today as a primary commercial, industrial, educational, and cultural center for this region. From the ship, it’s a short walk to a cruise highlight at the incredible complex of the Smithsonian-affiliated National Mississippi River Museum & Aquarium. Ask about our Current Savings and our Pre-Cruise Packages which include a premium hotel stay and transportation to the ship.
You'll traverse three rivers (the Mississippi, Ohio and Cumberland) en route from Memphis to Nashville, or vice versa. Viking has only one ship on this river, the upscale, 450-foot Viking Mississippi. The eight-day New Orleans & Southern Charms is the shortest itinerary available, while the 22-day Grand Mississippi Voyage covers the entire river, from New Orleans to St. Paul.

Admire the historic mansions and grand homes atop its bluffs, and delve into America’s Civil War history. Delight in the region’s famed Southern cuisine and sample Memphis’s renowned barbecue, alongside artisan beers. Birthplace of American music—blues, jazz and soul—the Mississippi celebrates its musical heritage in the towns and cities that line its legendary shores.
You'll also call on a historic Missouri trading post in Cape Girardeau (a French river port). Beginning and ending in the vibrant city of New Orleans, this incredible journey celebrates the rich heritage and festive spirit of a region where music is the common language and history can be found around every bend in the river. Travel in the comfort of our new fleet as you discover fascinating port towns, including Natchez, with a unique blend of African, British, and French culture. Over two weeks, you'll visit Native American burial grounds and archeological sites in West Virginia and learn about the underground railroad in Ohio.
The Lower Mississippi River is home to many of the confederate historical landmarks and Civil War memorials, as well as beautiful plantations, the expansive estate of Elvis Presley, and the grand city of New Orleans. Other interesting sites include the houses of Huckleberry Finn and Becky Thatcher. You can’t miss Old Fort Madison, which brings history to life and allows visitors to experience the life of a soldier during the war of 1812. Lastly, enjoy a glass of wine at one of the area’s wineries to end the day before returning to the cruise ship.
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